AnaSpec has announced the release of 21 new anti-Tau antibodies. Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, six isoforms, ranging between 352 and 441 amino acids in length, are produced as a result of alternative RNA splicing. The expression of Tau isoforms is developmentally-regulated, as only the smallest Tau polypeptide is expressed in the fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer’s disease. Anti- phospho-Tau antibodies are used to identify specific amino acids that are phosphorylated in Tau from normal brains and Alzheimer’s disease brains.
This article was published in Drug Discovery & Development magazine: Vol. 11, No. 2, February, 2008, pp. 16.
Filed Under: Drug Discovery